Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


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Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


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Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.


The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.


Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.


Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.


"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.


Major technology companies also report next week, but the bar for the sector has been lowered even further.


Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.


Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.


Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.


CASH POURING IN, HOUSING DATA COULD HELP


Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.


The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.


"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.


"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."


Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.


Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.


The new home sales report on Friday is expected to show a 2.1 percent increase.


The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.


Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.


The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.


"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.


"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."


(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)



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Foreigners still trapped in Sahara hostage crisis


ALGIERS/IN AMENAS, Algeria (Reuters) - More than 20 foreigners were captive or missing inside a desert gas plant on Saturday, nearly two days after the Algerian army launched an assault to free them that saw many hostages killed.


The standoff between the army and al Qaeda-linked gunmen - one of the biggest international hostage crises in decades - entered its fourth day, having thrust Saharan militancy to the top of the global agenda.


The number and fate of victims has yet to be confirmed, with the Algerian government keeping officials from Western countries far from the site where their countrymen were in peril.


Reports put the number of hostages killed at between 12 to 30, with possibly dozens of foreigners still unaccounted for - among them Norwegians, Japanese, Britons, Americans and others.


The U.S. State Department said on Friday one American, Frederick Buttaccio, had died but gave no further details.


On Saturday, the Algerian military was holding the vast residential barracks at the In Amenas gas processing plant, while gunmen were holed up in the industrial plant itself with an undisclosed number of hostages, making it difficult for Algerian special forces to intervene.


The army is surrounding the plant, and helicopters are monitoring the area, Algerian state radio said, quoting a reporter in the city of In Amenas.


Scores of Westerners and hundreds of Algerian workers were inside the heavily fortified compound when it was seized before dawn on Wednesday by Islamist fighters who said they wanted a halt to a French military operation in neighboring Mali.


Hundreds escaped on Thursday when the army launched an operation, but many hostages were killed in the assault. Algerian forces destroyed four trucks holding hostages, according to the family of a Northern Irish engineer who escaped from a fifth truck and survived.


Leaders of Britain, Japan and other countries have expressed frustration that the assault was ordered without consultation and officials have grumbled at the lack of information. Many countries also withheld details about their missing citizens to avoid releasing information that might aid the captors.


An Algerian security source said 30 hostages, including at least seven Westerners, had been killed during Thursday's assault, along with at least 18 of their captors. Eight of the dead hostages were Algerian, with the nationalities of the rest of the dead still unclear, he said.


Algeria's state news agency APS put the total number of dead hostages at 12, including both foreigners and locals.


The base was home to foreign workers from Britain's BP, Norway's Statoil and Japanese engineering firm JGC Corp and others.


Norway says eight Norwegians are still missing. JGC said it was missing 10 staff. Britain and the United States have said they have citizens unaccounted for but have not said how many.


The Algerian security source said 100 foreigners had been freed but 32 were still unaccounted for.


"We must be prepared for bad news this weekend but we still have hope," Norwegian Prime Minister Jens Stoltenberg said.


A U.S. official said on Friday a U.S. flight carrying wounded people from many countries had left Algeria, without giving further details.


The attack has plunged international capitals into crisis mode and is a serious escalation of unrest in northwestern Africa, where French forces have been in Mali since last week fighting an Islamist takeover of Timbuktu and other towns.


"We are still dealing with a fluid and dangerous situation where a part of the terrorist threat has been eliminated in one part of the site, but there still remains a threat in another part," British Prime Minister David Cameron told his parliament.


Two Japanese, two Britons and a French national were among the seven foreigners confirmed dead in the army's storming, the Algerian security source told Reuters. One British citizen was killed when the gunmen seized the hostages on Wednesday.


"(The army) is still trying to achieve a ‘peaceful outcome' before neutralizing the terrorist group that is holed up in the (facility) and freeing a group of hostages that is still being held," Algeria's state news agency said on Friday, quoting a security source.


MULTINATIONAL INSURGENCY


Algerian commanders said they moved in on Thursday about 30 hours after the siege began, because the gunmen had demanded to be allowed to take their captives abroad.


A French hostage employed by a French catering company said he had hidden in his room for 40 hours under the bed before he was rescued by Algerian troops, relying on Algerian employees to smuggle him food with a password.


"I put boards up pretty much all round," Alexandre Berceaux told Europe 1 radio. "I didn't know how long I was going to stay there ... I was afraid. I could see myself already ending up in a pine box."


The captors said their attack was a response to the French military offensive in neighboring Mali. However, some U.S. and European officials say the elaborate raid probably required too much planning to have been organized from scratch in the single week since France first launched its strikes.


Paris says the incident proves its decision to fight Islamists in neighboring Mali was necessary.


Security in the half-dozen countries around the Sahara desert has long been a preoccupation of the West. Smugglers and militants have earned millions in ransom from kidnappings.


The most powerful Islamist groups operating in the Sahara were severely weakened by Algeria's secularist military in a civil war in the 1990s. But in the past two years the regional wing of Al Qaeda gained fighters and arms as a result of the civil war in Libya, when arsenals were looted from Muammar Gaddafi's army.


Al Qaeda-linked fighters, many with roots in Algeria and Libya, took control of northern Mali last year, prompting the French intervention in that poor African former colony.


The apparent ease with which the fighters swooped in from the dunes to take control of an important energy facility, which produces some 10 percent of the natural gas on which Algeria depends for its export income, has raised questions over the value of outwardly tough Algerian security measures.


Algerian officials said the attackers may have had inside help from among the hundreds of Algerians employed at the site.


U.S. Defense Secretary Leon Panetta said those responsible would be hunted down: "Terrorists should be on notice that they will find no sanctuary, no refuge, not in Algeria, not in North Africa, not anywhere. ... Those who would wantonly attack our country and our people will have no place to hide."


(Additional reporting by Ali Abdelatti in Cairo, Eamonn Mallie in Belfast, Gwladys Fouche in Oslo, Mohammed Abbas in London, Padraic Halpin and Conor Humphries in Dublin, Andrew Quinn and David Alexander in Washington; Editing by Giles Elgood)



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How Your Great-Grandmother’s Hobby Is Transforming One Alabama Town






Natalie Chanin’s life-changing epiphany struck while standing on a New York City street corner.


For days, she had traversed throughout the city with a trash bag of her deconstructed T-shirts, seeking a manufacturer to help her make them. None of them, however, understood what kind of stitching she wanted on her creations, which had become popular in New York fashion circles after she made one on a whim and wore it to a party. Chanin was frustrated.






But then, she remembered a group of women who constructed hand-made quilts with bold stitching passed down through the generations. Chanin envisioned those stitches on her deconstructed T-shirts, She believed that those women could help her fuse the past with the present.


So, like a modern-day Scarlett O’Hara, Chanin knew where her immediate future lay, and it was back home in Florence, Ala. When Chanin returned to Florence in 2000, it was a much different place than when she left it in the 1980s. Then, the historic quaint town was the T-shirt capitol of the world, thanks to a thriving textile industry that employed thousands.


But a decade later, that industry had nearly vanished. People were unemployed in the town of 40,000 and warehouses were closed. The cotton once used for T-shirts was now shipped aboard. Chanin squarely blames NAFTA for these changes.


Public Citizen, a non-profit grassroots organization, cites that Alabama lost 118,125 manufacturing jobs from 1994 to 2012. The Bureau of Labor Statistics stated in a 1995 report that while the textile industry was seeing employment decline in the 1980s because of technology and overseas jobs, but it noted, “Future employment levels will be affected by the North America Free Trade Agreement” and that job loss would be “incremental” over the years.


NAFTA was touted as a good thing by many people because it would ease trade regulations and increased investment between the United States, Canada and Mexico. In 1993, President Bill Clinton signed the legislation, saying at the time: “NAFTA means jobs, American jobs, and good-paying American jobs. If I didn’t believe that, I wouldn’t support this agreement.”


Chanin doesn’t proclaim to be an expert on NAFTA, but the trade agreement angers her, and she blames Clinton for it.


“I often wonder if he regrets NAFTA,” Chanin says. “NAFTA helped to put a nail in the coffin of manufacturers in America. It created fear and anger, and we didn’t get the open commerce we wanted.”


The unemployment and the textile industry’s death in Florence haunted Chanin. She says she did what she knew how to do – sew – and never had a plan to become an eco-friendly fashion leader, a cheerleader for artisan seamstresses or a poster girl for Made in the USA. But that’s exactly what happened.


Chanin’s handcrafted, organic couture line – Alabama Chanin – has become emblematic of what’s possible when someone focuses on community commitment, sustainability and local traditions.


“I believe in ‘Made in America’ where at all possible,” Chanin says. “I see it almost as a matter of national security. It’s disturbing when you see that there are no steel mills in the South anymore. Food, clothing, shelter, right? Those are essential to sustaining life. Sewing was once a vital necessity for men and women.”


 Photo: Alabama Chanin


Chanin, 50, has certainly stitched her own path with a needle and thread.


On this January day, Chanin wears a black skirt, white boots and a white long-sleeve shirt with a black overlay T-shirt. Her trademark white hair frames her ageless face. Sitting at a long white table, she weaves her story like any good Southern storyteller. To fully grasp Chanin’s role in the Slow Fashion movement that promotes quality over quantity, you have to absorb Florence’s history and Chanin’s connection to it.


In the 1800s, Florence, a river town, had an abundance of water and streams that made it geographically suited as a cotton mill town. Villages soon cropped up where men, women and even children made underwear, union suits and undershirts for paltry wages. It was a rough life, dependent on soil, water and the seasons. Cotton was king, and it supported generations through the Civil War, the Great Depression and World War II.


Chanin’s Alabama roots cross many decades, and her family tree goes back seven generations in the area. Her great-grandmother knitted socks in east Florence’s Sweetwater Mill. Both of her grandmothers were avid quilters. Her parents still live around Florence and her 30-year-old son, Zachariah, moved to the town five years ago. Six years ago, Chanin’s daughter, Maggie, was born, and five months ago, her son became a father to Chanin’s first grandchild, Stella Ruth.


“There are five generations of my family alive and living here now,” she says. “It’s home, and that’s why I came back. It’s home.”


Sweet Home Alabama


When Chanin returned to Alabama, she set up shop in a three-bedroom brick house “10 miles as the crow flies” from Florence in a community known as Lovelace Crossing. “We say it like ‘loveless’,” Chanin says.


There, she began what she considered “just an art project” with the recycled, reworked T-shirts. She visited the quilting circle, and the women still met weekly, sold their completed quilts and reinvested the money into the community center – just as Chanin remembered. She told the women that she wanted to hire them for her project. But she hit a deadend.


“They said, ‘This is something we do for the community, we don’t want a job,” Chanin recalls. “They had gardens, grandchildren and they didn’t want the responsibility.”


Chanin persevered.


She placed an ad in the local newspaper seeking part-time seamstresses. Sixty people responded; she locked in 20 of them as independent contractors, creating a cottage industry that allowed women to work on their own terms and time. Many of these women lived in rural areas, had limited, if no, transportation and children to care for during the day.


The idea worked and evolved into the company Project Alabama. Eventually a few hundred stitchers sewed for her Project Alabama line. But, then the U.S. Department of Labor entered the picture in 2003 and investigated the independent contractor methods.


“We lost 90 percent of our workforce from one day to the next,” she says. “We refined the system because the Department of Labor was instrumental in showing us how the independent contractor system could work.”


The Birth of Alabama Chanin


“There are no rules; that is how art is born.” That’s the greeting on a lighted sign inside the front door of the Alabama Chanin spacious office and work space. Another handmade fabric sign states, “Waste Not Want Not.” On the back of two chairs, the words “Simplify, Simplify, Simplify” are carved into the natural wood. All of these sum up Chanin’s ethos.


Chanin left Project Alabama in 2006 amid differences about the company’s future regarding retaining jobs in her home town.


She soon started Alabama Chanin, leaving the house in Loveless and renting a 5,000-square-foot warehouse in Florence with a long history in the textile industry. The space was once part of a larger 100,000-square-feet complex that housed wall-to-wall sewing machines and workers who dyed fabric and made T-shirts.


Now a rack of Chanin’s designs – beautiful white coats with red stitching, appliqué skirts, stenciled T-shirts – has replaced the machines. Wire shelves hold Chanin’s white swatch books with hundreds of appliqué designs. Southern books, including the three she wrote, are displayed along with her examples of her jewelry and ceramic lines. Vintage Alabama quilts, which Chanin has “stabilized” with remnant fabrics and embroidery that tells stories, hang on one wall.


 Photo: Rinne Allen/Alabama Chanin


Unlike most clothing companies, Alabama Chanin doesn’t mass produce hundreds of items for retail, in an effort to maintain a policy of zero waste. Instead, each piece is a work-of-art, an item to be treasured, and like art, an Alabama Chanin garment is expensive – some range upwards of $ 5,000 and beyond. Fans often save for two or three years to own one.


Chanin uses only 100 percent organic cotton grown in Texas. It is spun into yarn in North Carolina, knitted into fabric in South Carolina and dyed in Tennessee and North Carolina. In the best case scenario, Chanin says, she attempts to use 100 percent American products, but occasionally organic domestic cotton is not available.


She no longer shows her designs at New York City Fashion Week, instead developing her brand through trunk shows, word-of-mouth and the Internet. While many designers keep their designs secret, Chanin does not. She is a zealous believer in the DIY and open-source movement. A significant part of her business is now centered on teaching workshops, writing books and her blog and selling custom sewing kits that allow others to create their own clothing and accessories.


It’s the operation of her business, however, that is most innovative.


Chanin employs only eleven people at the warehouse, but 30 seamstresses work as independent contractors. Over the years, Chanin estimates that more than 500 seamstresses in the Florence area have contributed to her design business. Her system is now similar to a cottage industry.


The concept hearkens to the Industrial Revolution when workers couldn’t travel from rural areas to urban ones. It allowed workers to have employment and also flexibility, something that is still needed in the 21st century.


“I’m just as proud of the system [we’ve developed] as for the designs that have been in Vogue,” she says. “Women are the primary caregivers whether it is a sick child or a caregiver for an elderly parent. They can work when they want, where they want and it empowers them to set their own schedule.”


A product isn’t made until a customer places an order. A bidding sheet for projects is sent to the 30 seamstresses via email and is also available at the warehouse. Seamstresses bid on projects, quoting Chanin a price that they think is fair depending on the project’s complexity with design, beading and appliqué. The bid may be in the thousands of dollars and take several months to complete as every piece is hand-sewn with not one stitch made on a machine.


 Photo: Rinne Allen/Alabama Chanin


The seamstress then invests her money into the project by purchasing the unassembled raw materials (fabric panels, thread, an Alabama Chanin label and other supplies) in person at the warehouse.


“When everyone is invested, you have a better ratio for success,” Chanin says. “They work by the project not by the time,” she explains. “We don’t ask. That’s their business. It’s totally up to them how they want to do it.”


When the project is finished, the seamstress initials the label and sells the creation back for the value she thinks it is worth. Rarely does an item fail to meet standards or a deadline. Ever conscious, Chanin tries to ensure everyone has a project during slow periods.


“We are always looking for ways to keep our artisans busy, and if we don’t, they will try to find other jobs because they have to feed their families,” she says. “These people are like our families. We care about them. We know their kids. We know who they are. We have become grandmothers together. We have broken bread together. We have prayed together. Keeping them in work is one of the responsibilities I have as a business owner.”


The Future Is Bright


Along back roads of the South, cotton fields extend for miles. The fluffy white bolls remain an integral part of the Southern economy and culture. No one knows this better than Southerners like Chanin and Florence fashion designer, Billy Reid, and his staff.


“This whole conversation sprang up about two years ago because there is an organization interested in bringing manufacturing back to the South,” Chanin says. “We were saying that it would be amazing if we could have vertical manufacturing here from growing the cotton to cutting and sewing it.”


Chanin gives credit to K.P. McNeill, who works for Billy Reid, for finding the six-acre untouched and unfarmed spot for the organic cotton experiment. From there, Chanin calls the farming adventure “a miraculous journey.”


“We found two sacks of seeds after we couldn’t find any,” she says. “We didn’t have a tractor and suddenly we had a tractor. We didn’t have a planter and then we had a planter.”


A severe drought threatened to kill the cotton crop, but amazingly, the cotton grew. Last October, Chanin closed her warehouse for the day and headed to the cotton patch to attend Alabama Chanin and Billy Reid Cotton Picking Party and Field Day. Family, friends and the community were invited to join Chanin. She hoped that people would learn about organic farming and the future possibilities that exist for Florence textile industry. While the acreage only produced a bale and half of cotton, it offered hope for the next season.


For Chanin, growing jobs was once her primary concern, but she has expanded her mission to include cultivating DIY ingenuity and, now, tackling the land. Her latest farming project should not surprise those who know and admire Chanin. After all, she believes that other businesses and designers should simply follow their heart.


“It’s about making the right decisions which aren’t always the easiest decisions,” Chanin says. “But every time I’ve made the right decision, I’ve been rewarded.”



Suzi Parker is an Arkansas-based political and cultural journalist whose work frequently appears in The Washington Post and The Christian Science Monitor. She is the author of two books. @SuziParker | TakePart.com 


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Marla Sokoloff Blogs: Adventures in Baby Traveling

Marla Sokoloff's Blog: Adventures in Baby Traveling
Shady ladies in Hawaii – Courtesy Marla Sokoloff


Our celebrity blogger Marla Sokoloff is a new mama!


Since audiences first got to know her at age 12 as Gia on Full House, Sokoloff has had many memorable TV roles — Jody on Party of Five, Lucy on The Practice, Claire on Desperate Housewives – as well as turns on the big screen in Whatever It Takes, Dude, Where’s My Car? and Sugar & Spice.


Sokoloff, 32, also sings and plays guitar and released an album, Grateful, in 2005.


She wed her husband, music composer Alec Puro, in November 2009 and the couple — plus pup Coco Puro — make their home in Los Angeles.


You can find Marla, now mom to 11-month-old daughter Elliotte Anne, on Twitter.


Happy 2013! I don’t know about you, but I’m completely amazed at how fast 2012 flew by! I must admit, on New Year’s Day I found myself a little weepy to say goodbye to the year that my little Elliotte came into this world. I realized that as long as I’m on this earth I will always have a soft spot for the year 2012, as it was a complete life and game-changer for me. (Clearly it’s also the year that turned me into a total sap!)


As far as resolutions go, I have a few. They include the usual suspects (exercise more, get more sleep, drink more than four sips of water per day!) but my main focus is going to be on my beloved iPhone and our very dysfunctional relationship.


I really want to work on being in the present and putting that thing down so I can suck up every delicious moment with my family. The social media and pinboards will just have to wait until after my daughter goes to bed. Baby steps!


Last week we hit a huge milestone … Elliotte took her first steps and is now walking (albeit a bit drunk-like) almost on her own! The moment was truly unbelievable and one that left me in tears (shocking … I know) as I was simply overwhelmed with joy. I was just so proud of her.


This is where my resolution isn’t a good thing because — had I not had my trusty iPhone glued to my body — I might have missed the moment. Her grandparents would have killed me! I’m just saying…


Marla Sokoloff's Blog: Adventures in Baby Traveling
Happy New Year! – Courtesy Marla Sokoloff


We spent our Christmas vacation in paradise on the Big Island of Hawaii, but I’m here to tell you that getting there was nothing short of a nightmare. I’m not going to lie or candy-coat this blog at all because this experience was one I never want to relive.


All of my friends warned me about baby airplane travel … basically it could go either way. Kids are wild cards and you never really know what you’re going to get. So in preparation for my little wild card, I boarded our flight armed with earplugs and chocolates for the innocent passengers that could potentially be caught in the line of fire, so to speak. All the while knowing that I will never need to bring out said earplugs … I mean, my child is perfect after all!


This wasn’t Elliotte’s first flight — over the summer we traveled to San Francisco and my little angel slept for the hour flight each way, so I was certain we had this Hawaiian excursion in the bag.


I came equipped with two giant diaper bags. One was filled with diaper bag essentials (diapers, wipes, pacifiers, bottles, change of clothes for both of us) and the other ridiculously large bag was filled with toys and snacks. So many toys and snacks!! If this plane went down, Elliotte could feed the whole cabin with her copious supply of puffs and Cheerios. Basically the plan was, if this kid wasn’t sleeping, I was going to keep her busy and well-fed!


My special edition diaper bag also contained an emergency item. An SOS of sorts. An article that is generally considered a baby no-no in my house, but one that was only to be revealed if absolutely 100 percent necessary. Friends, I’m talking about the iPad. I loaded my secret weapon up with episodes of Sesame Street and adorable farm animal applications that looked like they would keep Elliotte entertained for at least a temper tantrum or two.


Very much like the aforementioned earplugs, I felt pretty confident that our no-no item wouldn’t be making an appearance.


Marla Sokoloff's Blog: Adventures in Baby Traveling
Before takeoff… – Courtesy Marla Sokoloff


As our flight took off, I could see that Elliotte was not the happy camper I know and love. Her face turned beet-red within seconds and she was thrashing in her carseat as if it was a torture device. The tears were flowing fast and her scream was one that could not be silenced.


I looked at my husband, whose eyes said, “Bring out the iPad!!” but I knew it was way too early in our journey to pull such tricks out of sleeves.


As Alec handed out the chocolate and earplugs to our unlucky neighbors, I brought out some of Elliotte’s favorite toys. Every toy that was presented was met with a louder scream. I moved on to my trusted stash of snacks — surely a handful of puffs would soothe this outburst. Fail. I sang. I danced. I peek-a-booed. Nothing.


How can this be? The seat belt sign hasn’t even been turned off yet and I have pretty much emptied out the contents of my special-edition diaper bag!


Once the captain decided to put me out of my misery and turned the seat belt sign off, I ripped Elliotte out of her carseat (the one I brought thinking she would sleep in) and decided a nice walk down the aisle would do us both some good.


That mission was quickly aborted as the scream-fest continued to unaffected rows that were surely enjoying their cocktails and weekly gossip magazines.


Marla Sokoloff's Blog: Adventures in Baby Traveling
My beach baby in Hawaii – Courtesy Marla Sokoloff


I handed her off to my husband and I took a much-needed break, as well as the first deep breath I had taken since leaving Los Angeles International Airport. We were now three-and-a-half hours into our six-hour flight and Elliotte showed no signs of slowing down. It was in this moment that I turned to my family and saw the chaos.


My seat was littered with toys and Cheerios and my poor child looked like a complete mess. Her face was tear-stained and her clothes were covered in squeezable applesauce. (Another failed mission.)


I knew it was time to bring out the big guns. Elmo needed to step in and he better be bringing his A-game.


I placed Elliotte on my lap and out came the iPad. Images of all of my favorite characters appeared on the screen and I instantly felt comforted by my childhood friends. Not only because they are the same characters that were my source of calm as a child, but also I knew they were the lifesavers we so desperately needed.


Well … I guess iPads and big yellow birds aren’t that comforting to teething babies that are 30,000 feet up in the air. The iPad went flying and I sunk into my seat holding my very unhappy girl tight. I was officially out of ideas.


Marla Sokoloff's Blog: Adventures in Baby Traveling
Hawaiian fun in the sun – Courtesy Marla Sokoloff


A kind woman in front of me asked to hold Elliotte. She saw in my eyes that I was breaking down and she was a mom who got it. She understood. She didn’t judge or hate us for disrupting the beginning of her holiday vacation — she was happy to help because she had once been in our shoes with her own child. Elliotte enjoyed the break from her parents and was actually smiling in her arms.


We finally arrived in paradise and upon landing, Alec and I decided that we were moving to Hawaii as we were never going to step foot on a plane ever again.


In all fairness, in between Thanksgiving and Christmas, Elliotte went from having two teeth to eight teeth so I think the plane and cabin pressure exacerbated any existing pain she was already having. Our journey home was slightly better and she even slept for two beautiful hours!


Thank you for letting me share my story — I would absolutely love to hear some of your travel woes! I’m sure it’s even more fun for those of you who have multiple children.


Don’t forget to follow me on Twitter @marlasok or leave your comments below!


Until next time … xo,


– Marla Sokoloff


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Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


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Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


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Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.


The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.


Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.


Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.


"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.


Major technology companies also report next week, but the bar for the sector has been lowered even further.


Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.


Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.


Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.


CASH POURING IN, HOUSING DATA COULD HELP


Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.


The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.


"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.


"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."


Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.


Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.


The new home sales report on Friday is expected to show a 2.1 percent increase.


The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.


Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.


The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.


"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.


"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."


(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)



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Hostages still held after Sahara assault


ALGIERS (Reuters) - At least 22 foreign hostages remained unaccounted for on Friday after Algerian forces stormed a desert gas complex to free hundreds of captives taken by Islamist gunmen, an operation in which dozens of the hostages were killed.


With Western leaders clamoring for details of the assault they said Algeria had launched on Thursday without consulting them, a local source said the gas base was still surrounded by Algerian special forces and some hostages remained inside.


Thirty hostages, including several Westerners, were killed during the storming on Thursday, the source said, along with at least 11 of their captors, who said they had taken the site as retaliation for French intervention against Islamists in neighboring Mali.


Fourteen Japanese were among those still unaccounted for by the early hours of Friday, their Japanese employer said, while Norwegian energy company Statoil, which runs the Tigantourine gas field with Britain's BP and Algeria's national oil company, said eight Norwegian employees were still missing.


An Irish engineer who survived said he saw four jeeps full of hostages blown up by Algerian troops whose commanders said they moved in about 30 hours after the siege began because the gunmen had demanded to be allowed to take their captives abroad.


The crisis posed a serious dilemma for Paris and its allies as French troops attacked the hostage-takers' al Qaeda allies in Mali. It also left question marks over the ability of OPEC-member Algeria to protect vital energy resources and strained its relations with Western powers.


Two Japanese, two Britons and a French national were among at least seven foreigners killed, the source told Reuters. Eight dead hostages were Algerian. The nationalities of the rest, as well as of perhaps dozens more who escaped, were unclear. Some 600 local Algerian workers, less well guarded, survived.


A diplomatic source said Britain had not received any information to suggest the hostage situation had ended. "The situation is still really fluid on the ground. We have no information from the Algerian authorities that it's over."


Japan's Prime Minister Shinzo Abe has cancelled part of his trip in Southeast Asia, his first overseas trip since taking office, and will fly home early due to the hostage crisis, Japan's senior government spokesman said on Friday.


"The action of Algerian forces was regrettable," said Japan's Chief Cabinet Secretary Yoshihide Suga, adding Tokyo had not been informed of the operation in advance.


Americans, Romanians and an Austrian have also been mentioned by their governments as having been captured by the militants, who call themselves the "Battalion of Blood" and have demanded France end its week-old offensive in Mali.


Underlining the view of African and Western leaders that they face a multinational Islamist insurgency across the Sahara - a conflict that prompted France to send hundreds of troops to Mali last week - the official source said only two of the 11 dead militants were Algerian, including the squad's leader.


The bodies of three Egyptians, two Tunisians, two Libyans, a Malian and a Frenchman - all assumed to have been hostage-takers - were found, the security source said.


The group had claimed to have dozens of guerrillas on site and it was unclear whether any militants had managed to escape.


The overall commander, Algerian officials said, was Mokhtar Belmokhtar, a veteran of Afghanistan in the 1980s and Algeria's bloody civil war of the 1990s. He appears not to have been present and has now risen in stature among a host of Saharan Islamists, flush with arms and fighters from chaotic Libya, whom Western powers fear could spread violence far beyond the desert.


"NO TO BLACKMAIL"


Algeria's government made clear it remains implacably at odds with Islamist guerrillas who remain at large in the south, years after the civil war in which some 200,000 people died. Communication Minister Mohamed Said repeated their refusal ever to negotiate with hostage-takers.


"We say that in the face of terrorism, yesterday as today as tomorrow, there will be no negotiation, no blackmail, no respite in the struggle against terrorism," he told APS news agency.


British Prime Minister David Cameron, who warned people to prepare for bad news and who cancelled a major policy speech on Friday to deal with the situation, said through a spokesman that he would have liked Algeria to have consulted before the raid.


A Briton and an Algerian were also killed on Wednesday.


U.S. officials had no clear information on the fate of Americans, though a U.S. military drone had flown over the area. Washington, like its European allies, has endorsed France's move to protect the Malian capital by mounting air strikes last week and now sending 1,400 ground troops to attack Islamist rebels.


A U.S. official said on Thursday it would provide transport aircraft to help France with a mission whose vital importance, President Francois Hollande said, was demonstrated by the attack in Algeria. Some fear, however, that going on the offensive in the remote region could provoke more bloodshed closer to home.


The apparent ease with which the fighters swooped in from the dunes to take control of an important energy facility, which produces some 10 percent of the natural gas on which Algeria depends for its export income, has raised questions over the value of security measures that are outwardly draconian.


(Additional reporting by Ali Abdelatti in Cairo, Eamonn Mallie in Belfast, Gwladys Fouche in Oslo, Mohammed Abbas in London and Padraic Halpin and Conor Humprhies in Dublin; writing by Alastair Macdonald and Philippa Fletcher; editing by Peter Millership, Michael Perry and Will Waterman)



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Inspiring Singers Outshine American Idol's Feuding Judges






American Idol










01/17/2013 at 11:00 PM EST







From left: Randy Jackson, Mariah Carey, Ryan Seacrest, Nicki Minaj and Keith Urban


George Holz/FOX


The second episode of American Idol delivered more drama, but a handful of singers managed to eclipse the ongoing feud between new judges Mariah Carey and Nicki Minaj. And that's no easy task considering one of the battling divas is wearing a blonde and pink wig.

The night's most memorable contestant was Lazaro Arbos. As he entered the audition room, one thing became immediately clear: the 21-year-old from Naples, Fla., had a severe stutter. Arbos, who emigrated from Cuba when he was 10, told viewers that he had few friends growing up due to his speech impediment.

But something magical happened when he began to sing. His stutter vanished and he gave a moving performance of "Bridge Over Troubled Water." As the judges unanimously put him through to Hollywood, Arbos dissolved into tears.

Equally inspiring was Mariah Pulice, a 19-year-old restaurant hostess from Darien, Ind. The last two years have been difficult for Pulice, who told judges she was recovering from anorexia. "If there was no music," she said, "I would not be alive." After singing the Beatles' "Let it Be," the judges were unanimous in their praise. "I really, really, really felt that song coming from you," said Minaj.

Carey agreed: "You touched me," she said. "I know what it's like to have to sing through tears. I'm proud of you."

But it wasn't all drama and emotion. Minaj started a baffling trend of asking handsome singers if they had a girlfriend. (She also managed to charm the shirts off of a couple of them, although you get the feeling they were happy to show their abs on national TV.) "You have a hole in your pants," she told one contestant. "Why are you looking?" he shot back.

And poor Keith Urban. Sitting between Minaj and Carey, he found himself in the crossfire. "I feel like a scratching post," he said at one point, before repeatedly banging his head on the table.

The judges found a lot of talent in Chicago. All told, 46 contestants were put through to Hollywood. The competition will head to Charlotte, N.C., next Wednesday.

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Food servers more vulnerable to legal threats


WASHINGTON (AP) — People with severe food allergies have a new tool in their attempt to find menus that fit their diet: federal disabilities law. And that could leave schools, restaurants and anyplace else that serves food more vulnerable to legal challenges over food sensitivities.


A settlement stemming from a lack of gluten-free foods available to students at a Massachusetts university could serve as a precedent for people with other allergies or conditions, including peanut sensitivities or diabetes. Institutions and businesses subject to the Americans With Disabilities Act could be open to lawsuits if they fail to honor requests for accommodations by people with food allergies.


Colleges and universities are especially vulnerable because they know their students and often require them to eat on campus, Eve Hill of the Justice Department's civil rights division says. But a restaurant also could be liable if it blatantly ignored a customer's request for certain foods and caused that person to become ill, though that case might be harder to argue if the customer had just walked in off the street, Hill said.


The settlement with Lesley University, reached last month but drawing little attention, will require the Cambridge, Mass., institution to serve gluten-free foods and make other accommodations for students who have celiac disease. At least one student complained to the federal government after the school would not exempt the student from a meal plan even though the student couldn't eat the food.


"All colleges should heed this settlement and take steps to make accommodations," says Alice Bast, president and founder of the National Foundation for Celiac Awareness. "To our community this is definitely a precedent."


People who suffer from celiac disease don't absorb nutrients well and can get sick from the gluten found in wheat, rye and barley. The illness, which affects around 2 million Americans, causes abdominal pain, bloating and diarrhea, and people who have it can suffer weight loss, fatigue, rashes and other problems. Celiac is a diagnosed illness that is more severe than gluten sensitivity, which some people self-diagnose.


Ten years ago, most people had never heard of celiac disease. But awareness has exploded in recent years, for reasons that aren't entirely clear. Some researchers say it was under-diagnosed, others say it's because people eat more processed wheat products like pastas and baked goods than in past decades, and those items use types of wheat that have a higher gluten content.


Gluten-free diets have expanded beyond those with celiac disease. Millions of people are buying gluten-free foods because they say they make them feel better, even if they don't have a wheat allergy. Americans were expected to spend $7 billion on gluten-free foods last year.


With so many people suddenly concerned with gluten content, colleges and universities have had to make accommodations. Some will allow students to be exempted from meal plans, while others will work with students individually. They may need to do even more now as the federal government is watching.


"These kids don't want to be isolated," Bast says. "Part of the college experience is being social. If you can't even eat in the school cafeteria then you are missing out on a big part of college life."


Under the Justice Department agreement, Lesley University says it will not only provide gluten-free options in its dining hall but also allow students to pre-order, provide a dedicated space for storage and preparation to avoid cross-contamination, train staff about food allergies and pay a $50,000 cash settlement to the affected students.


"We are not saying what the general meal plan has to serve or not," Hill says. "We are saying that when a college has a mandatory meal plan they have to be prepared to make reasonable modifications to that meal plan to accommodate students with disabilities."


The agreement says that food allergies may constitute a disability under the Americans With Disabilities Act, if they are severe enough. The definition was made possible under 2009 amendments to the disability law that allowed for episodic impairments that substantially limit activity.


"By preventing people from eating, they are really preventing them from accessing their educational program," Hill said of the school and its students.


Mary Pat Lohse, the chief of staff and senior adviser to Lesley University's president, says the school has been working with the Justice Department for more than three years to address students' complaints. She says the school has already implemented most parts of the settlement and will continue to update policies to serve students who need gluten-free foods.


"The settlement agreement provides a positive road map for other colleges and universities to follow with regard to accommodating students with food allergies and modifying existing food service plans," Lohse said.


Some say the Justice Department decision goes too far. Hans von Spakovsky, a fellow at the conservative Heritage Foundation who worked in the civil rights division of the Justice Department under President George W. Bush, says food allergies shouldn't apply under the disability act. He adds that the costs could be substantial when schools are already battling backlash from high tuition costs.


"I certainly encourage colleges and universities to work with students on this issue, but the fact that this is a federal case and the Justice Department is going to be deciding what kind of meals could be served in a dining hall is just absurd," he said.


Whether the government is involved or not, schools and other food service establishments are likely to hear from those who want more gluten-free foods. Dhanu Thiyagarajan, a sophomore at the University of Pittsburgh, said she decided to speak up when she arrived at school and lost weight because there were too few gluten-free options in the cafeteria. Like Lesley University, the University of Pittsburgh requires that on-campus students participate in a meal plan.


Thiyagarajan eventually moved off campus so she could cook her own food, but not before starting an organization of students who suffer from wheat allergies like hers. She says she is now working with food service at the school and they have made a lot of progress, though not enough for her to move back on campus.


L. Scott Lissner, the disability coordinator at Ohio State University, says he has seen similar situations at his school, though people with food allergies have not traditionally thought of themselves as disabled. He says schools will eventually have to do more than just exempt students from a meal plan.


"This is an early decision on a growing wave of needs that universities are going to have to address," he said of the Lesley University agreement.


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